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Math

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PROBLEM

Practice Another
Unclogging Arteries Research done in the 1930s by the French physiologist Jean Poiseuille showed that the resistance RR of a blood vessel of length / and radius rr is R=klr4R=\frac{k l}{r^{4}}, where kk is a constant. Suppose a dose of the drug TPA increases rr by 8%8 \%. How will this affect the resistance RR ? Assume that ll is constant.
dRR=\frac{d R}{R}=

STEP 1

What is this asking?
If the radius of a blood vessel increases, how much does the resistance of the blood vessel decrease?
Watch out!
The radius is increasing, so we expect the resistance to decrease.
Don't mix up a decrease with an increase!

STEP 2

1. Set up the equation
2. Calculate the new radius
3. Calculate the new resistance
4. Calculate the percent change in resistance

STEP 3

We're given the formula R=klr4R = \frac{kl}{r^4}, where kk is a constant and ll is also constant.
This tells us how the resistance RR relates to the radius rr.

STEP 4

The problem says the drug increases rr by 8%.
This means the new radius, let's call it rr', is the original radius rr plus 8% of rr.

STEP 5

Mathematically, we can write this as:
r=r+0.08r=1.08rr' = r + 0.08r = 1.08r So the new radius rr' is 1.08 times the original radius.

STEP 6

Now, let's find the new resistance, which we'll call RR'.
We can use the same formula, but with the new radius rr':
R=kl(r)4R' = \frac{kl}{(r')^4}

STEP 7

We know r=1.08rr' = 1.08r, so we can substitute that in:
R=kl(1.08r)4=kl1.084r4R' = \frac{kl}{(1.08r)^4} = \frac{kl}{1.08^4 r^4}

STEP 8

We can rewrite this as:
R=11.084klr4R' = \frac{1}{1.08^4} \cdot \frac{kl}{r^4} Notice that klr4\frac{kl}{r^4} is just the original resistance, RR!
So,
R=11.084RR' = \frac{1}{1.08^4} R R11.3605R0.735RR' \approx \frac{1}{1.3605} R \approx 0.735 R

STEP 9

The percent change is calculated as:
New ValueOld ValueOld Value100%\frac{\textbf{New Value} - \textbf{Old Value}}{\textbf{Old Value}} \cdot 100\%

STEP 10

In our case, the new value is RR' and the old value is RR:
RRR100%\frac{R' - R}{R} \cdot 100\%

STEP 11

We know R0.735RR' \approx 0.735R, so let's plug that in:
0.735RRR100%=0.265RR100%=0.265100%=26.5%\frac{0.735R - R}{R} \cdot 100\% = \frac{-0.265R}{R} \cdot 100\% = -0.265 \cdot 100\% = -26.5\%

SOLUTION

The resistance RR decreases by approximately 26.5%.

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